N.A.S.S Dingwall Information Page
Phenylbutazone NSAIDs
(BRITISH) UK Trade name
products: (Butacote)
(AMERICAN) US Trade name
products which contain phenylbutazone include: (Azolid)
(Butazolodin) (Butazone) (Alka-Butazolidin) (Alka-Phenylbutazone)
(Alkabutazone) (Apo-Phenylbutazone) (Butatab) (Intrabutazone)
(Novobutazone)(Phenylone Plus)
INDICATION
A treatment used to relieve
pain, fever, and inflammation.
SIDE EFFECTS
Anaemia, decreased white blood
cells and blood platelets, confusion, agitation, high blood
pressure, pericarditis, myocarditis, blurred vision, hearing
loss, retinal detachment, swelling, nausea, vomiting, diarrhoea,
ulcers, kidney failure, bloody urine, hepatitis, high blood
sugar, thyroid goiter, itching, spots, blisters, and rashes.
INTERACTIONS and PRECAUTIONS
- Separate from the ingestion
of cholestyramine by 1 hour.
- Insulin and oral
hypoglycaemic agents may lower blood sugar more, when
taken with this medication.
- Anticoagulant medications
(warfarin) can increase the risk of bleeding.
- Phenytoin and lithium can
have elevated plasma levels, which could lead to their
toxicity
- Use with ACE inhibitors
(captopril, lisinopril, enalapril) can result in
decreased ACE inhibitor effect.
- Use with aspirin or alcohol
can promote stomach ulcers or bleeding.
- Use with beta-blockers
(propranolol, metoprolol, labetalol, carteolol) can
decrease their antihypertensive effect.
- Use with cephalosporin
class antibiotics may promote bleeding.
- Use with diuretics may
decrease diuretic effect.
USUAL DOSE
Adults: oral, 100 mg four times a day
Paediatrics (up to age 15): use not recommended.